The SINs (Smart Implantable Neurostimulators) project is focused on the development of soft- and hardware for the next generation neurostimulators. It is a collaboration between the Dutch Neuroscience Department of the Erasmus Medical Center, Neurasmus B.V., the Delft University of Technology and the Belgian BRAI²N group (Brain Research center Antwerp for Innovative & Interdisciplinary Neuromodulation).


Neurostimulation is the electrical stimulation of the nervous system, which may be used for the treatment of many medical conditions. The advantage of electrical stimulation over pharmaceutical means is that the stimulation can be applied at specific locations, limiting the side-effects experienced by the patient. Examples of such treatments include chronic pain management through spinal-cord stimulation, inhibiting the tremor observed in Parkinson patients through deep-brain stimulation or preventing epileptic seizures through vagus-nerve stimulation. In addition to limiting the side-effects of the treatment, neurostimulation allows for treatments not previously possible, for example, allowing the deaf to hear using a cochlear implant.


Due to the pervasive nature of aforementioned treatments, neurostimulators are implemented as wearable or even implantable devices. These are tightly-constrained embedded devices, expected to perform their safety-critical application on a limited battery supply for several years. The treatment-software running on these devices should be adjustable (e.g., to update a treatment plan) and monitored remotely, i.e., secured wireless communication is required.


Given these concerns and constraints, we are currently working on the following topics within our department:


Rapid prototyping of new medical treatments to improve current health care. Examples include a minimal-delay seizure-prevention treatment and tinnitus treatment;

Fault diagnosis and tolerance to guarantee correct functionality throughout a device’s lifetime, while minimizing the effect on the energy and power consumption;

Ultra-low-power and energy consumption to maximize the device lifetime; and

Security of wireless communication to prevent malicious third parties from harming a patient using the wireless link, e.g., by stealing private data or altering device configurations



For related publications see: SINS publications

SINS was developed under the Braininnovations consortium. Braininnovations was created as a joint venture to integrate the very rapid developments in brain research and technology in order to create new treatments for intractable diseases. Braininnovations originated when the Belgian BRAI²N group (Brain Research center Antwerp for Innovative & Interdisciplinary Neuromodulation) joined forces with Delft University of Technology and the Neuroscience Department of the Erasmus Medical Center/Neurasmus B.V., Rotterdam, both in the Netherlands. In an intensified bed-to-bench and bench-to-bed approach, Braininnovations bridges a gap in translational medicine by combining cutting edge technologies with the outcome of studies in neuroscience.


This project is still ongoing!


Contact Persons

  • Christos Strydis

  • Muhammad Ali Siddiqi

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